Depression, including depression w/ associated anxiety; anxiety or generalized anxiety disorder, including long-term treatment; social anxiety disorder (social phobia); panic disorder w/ or w/o agoraphobia. Prevention of relapses & recurrence of depression.
Depression 75 mg once daily; may be increased to 225 mg/day in moderate depression & 375 mg/day for severe depression. Generalized anxiety & social anxiety disorder Initially 75 mg/day; may be increased to 225 mg/day at not <4 days interval. Initially 37.5 mg/day for some patients w/ social anxiety disorder. Max: 225 mg/day. Panic disorder w/ or w/o agoraphobia Initially 37.5 mg/day for 4-7 days in outpatients followed by 75 mg/day. Max: 225 mg/day.
Increased suicidality. Monitor patients w/ raised IOP, acute narrow-angle glaucoma as mydriasis may occur. Recent MI or unstable heart disease. Routine BP monitoring is advisable. History of convulsion, bipolar disorder, aggression, predisposal to bleeding. Monitor serum cholesterol levels during long-term treatment. Patients taking diuretics or vol-depleted. Do not discontinue abruptly, dose tapering is recommended. Pregnancy & lactation. Childn <18 yr. Renal & hepatic impairment. Elderly.
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